Epigenetics and sarcoidosis

Eur Respir Rev. 2021 Jun 23;30(160):210076. doi: 10.1183/16000617.0076-2021. Print 2021 Jun 30.


Epigenetic modifications are emerging as important regulatory mechanisms of gene expression in lung disease, given that they are influenced by environmental exposures and genetic variants, and that they regulate immune and fibrotic processes. In this review, we introduce these concepts with a focus on the study of DNA methylation and histone modifications and discuss how they have been applied to lung disease, and how they can be applied to sarcoidosis. This information has implications for other exposure and immunologically mediated lung diseases, such as chronic beryllium disease, hypersensitivity pneumonitis, and asbestosis.

Publication types

  • Review

MeSH terms

  • DNA Methylation
  • Environmental Exposure
  • Epigenesis, Genetic
  • Humans
  • Lung Diseases*
  • Sarcoidosis* / diagnosis
  • Sarcoidosis* / genetics