Risk of symptomatic severe acute respiratory syndrome coronavirus 2 infection not associated with influenza vaccination in the 2019-2020 season

Influenza Other Respir Viruses. 2021 Nov;15(6):697-700. doi: 10.1111/irv.12880. Epub 2021 Jun 25.

Abstract

The association of influenza vaccine and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was assessed by test-negative design using data collected for a study of outpatient COVID-19-like illness with onset dates from June to September 2020. Multivariable logistic regression models examined the association between receipt of 2019-2020 influenza vaccine and PCR-confirmed SARS-CoV-2 with adjustment for potential confounders. Receipt of influenza vaccine during the 2019-2020 influenza season was not associated with increased odds of SARS-CoV-2 infection in adults (aOR 0.83, 95% CI 0.63 to 1.10) or children (aOR 0.92, 95% CI 0.47 to 1.80).

Keywords: COVID-19; PCR; SARS-CoV-2; influenza vaccine; outpatient.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • COVID-19*
  • Child
  • Humans
  • Influenza, Human* / epidemiology
  • Influenza, Human* / prevention & control
  • SARS-CoV-2
  • Seasons
  • Vaccination