Interleukin -17 and oxidative stress in children with immunoglobulin A vasculitis

Scand J Rheumatol. 2022 Jul;51(4):309-314. doi: 10.1080/03009742.2021.1926319. Epub 2021 Jun 25.

Abstract

Objective: We aimed to investigate levels of interleukin-17 (IL-17) and oxidative stress in the active phase of immunoglobulin A vasculitis (IgAV) and determine whether a relationship exists among IL-17, oxidative stress, and system involvement.

Method: Patients diagnosed with IgAV, who were not given non-steroidal anti-inflammatory or steroidal drugs within a month, were enrolled. Blood samples were taken in the active and remission phases of the disease. Malondialdehyde (lipid peroxidation marker), 8-hydroxydeoxyguanosine (DNA oxidation marker), total oxidant status (TOS) and total antioxidant status (TAS) levels for oxidative stress, and IL-17 levels were measured.

Results: Forty-four patients aged 1.91-15.41 years were enrolled. IL-17 and TAS levels were significantly higher in the active phase of the disease than in the remission phase. 8-Hydroxydeoxyguanosine levels were higher in patients with gastrointestinal involvement than in patients without involvement in the active phase of the disease. A moderate positive correlation was observed between IL-17 and TAS in both active and remission phases.

Conclusion: Our results showed increased DNA oxidation in patients with gastrointestinal involvement in the active phase of IgAV, for the first time. Higher IL-17 and TAS levels in the active phase of the disease and positive correlations of TAS and IL-17 in both active and remission phases suggest that IL-17 and oxidative stress may be related.

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Antioxidants / metabolism
  • Child
  • Humans
  • IgA Vasculitis* / metabolism
  • IgA Vasculitis* / pathology
  • Immunoglobulin A
  • Interleukin-17* / metabolism
  • Oxidative Stress

Substances

  • Antioxidants
  • IL17A protein, human
  • Immunoglobulin A
  • Interleukin-17
  • 8-Hydroxy-2'-Deoxyguanosine