Enantiomeric cannabinoids: stereospecificity of psychotropic activity

Experientia. 1988 Sep 15;44(9):762-4. doi: 10.1007/BF01959156.

Abstract

The 1,1-dimethylheptyl homolog of (-)-(3R,4R)-7-hydroxy-delta-6- tetrahydrocannabinol (compound II) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Cannabinoids* / chemical synthesis
  • Cannabinoids* / pharmacology
  • Columbidae
  • Dose-Response Relationship, Drug
  • Rats
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Cannabinoids