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, 44 (9), 762-4

Enantiomeric Cannabinoids: Stereospecificity of Psychotropic Activity

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Enantiomeric Cannabinoids: Stereospecificity of Psychotropic Activity

R Mechoulam et al. Experientia.

Abstract

The 1,1-dimethylheptyl homolog of (-)-(3R,4R)-7-hydroxy-delta-6- tetrahydrocannabinol (compound II) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).

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