Commentary: Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome

doi:10.3389/fphys.2021.682567

Comment

. 2021 Jun 9:12:682567.

doi: 10.3389/fphys.2021.682567. eCollection 2021.

Commentary: Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome

Michelle M Monasky¹, Carola Rutigliani², Emanuele Micaglio¹, Carlo Pappone^{1

2}

Affiliations

¹ Arrhythmology Department, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
² Vita-Salute San Raffaele University, Milan, Italy.

PMID: 34177625
PMCID: PMC8220137
DOI: 10.3389/fphys.2021.682567

Comment

Commentary: Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome

Michelle M Monasky et al. Front Physiol. 2021.

. 2021 Jun 9:12:682567.

doi: 10.3389/fphys.2021.682567. eCollection 2021.

Authors

Michelle M Monasky¹, Carola Rutigliani², Emanuele Micaglio¹, Carlo Pappone^{1

2}

Affiliations

¹ Arrhythmology Department, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
² Vita-Salute San Raffaele University, Milan, Italy.

PMID: 34177625
PMCID: PMC8220137
DOI: 10.3389/fphys.2021.682567

No abstract available

Keywords: Brugada syndrome; CACNA1C; L-type calcium channel; drug; mutations; personalized medicine; pharmaceutical.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Comment on

Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome.
Di Mauro V, Ceriotti P, Lodola F, Salvarani N, Modica J, Bang ML, Mazzanti A, Napolitano C, Priori SG, Catalucci D. Di Mauro V, et al. Front Physiol. 2021 Jan 8;11:616819. doi: 10.3389/fphys.2020.616819. eCollection 2020. Front Physiol. 2021. PMID: 33488405 Free PMC article.

Cited by

The Mechanism of Ajmaline and Thus Brugada Syndrome: Not Only the Sodium Channel!
Monasky MM, Micaglio E, D'Imperio S, Pappone C. Monasky MM, et al. Front Cardiovasc Med. 2021 Dec 23;8:782596. doi: 10.3389/fcvm.2021.782596. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 35004896 Free PMC article. Review.
Brugada Syndrome: Warning of a Systemic Condition?
D'Imperio S, Monasky MM, Micaglio E, Ciconte G, Anastasia L, Pappone C. D'Imperio S, et al. Front Cardiovasc Med. 2021 Oct 15;8:771349. doi: 10.3389/fcvm.2021.771349. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 34722688 Free PMC article. Review.

References

1. Antzelevitch C., Pollevick G. D., Cordeiro J. M., Casis O., Sanguinetti M. C., Aizawa Y., et al. . (2007). Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation 115, 442–449. 10.1161/CIRCULATIONAHA.106.668392 - DOI - PMC - PubMed
1. Betzenhauser M. J., Pitt G. S., Antzelevitch C. (2015). Calcium channel mutations in cardiac arrhythmia syndromes. Curr. Mol. Pharmacol. 8, 133–142. 10.2174/1874467208666150518114857 - DOI - PMC - PubMed
1. Bourdin B., Shakeri B., Tetreault M. P., Sauve R., Lesage S., Parent L. (2015). Functional characterization of CaValpha2delta mutations associated with sudden cardiac death. J. Biol. Chem. 290, 2854–2869. 10.1074/jbc.M114.597930 - DOI - PMC - PubMed
1. Burashnikov E., Pfeiffer R., Barajas-Martinez H., Delpon E., Hu D., Desai M., et al. . (2010). Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death. Heart Rhythm. 7, 1872–1882. 10.1016/j.hrthm.2010.08.026 - DOI - PMC - PubMed
1. Ciconte G., Monasky M. M., Santinelli V., Micaglio E., Vicedomini G., Anastasia L., et al. . (2020). Brugada syndrome genetics is associated with phenotype severity. Eur. Heart J. 42:1082–90. 10.1093/eurheartj/ehaa942 - DOI - PMC - PubMed

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[1] Antzelevitch C., Pollevick G. D., Cordeiro J. M., Casis O., Sanguinetti M. C., Aizawa Y., et al. . (2007). Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation 115, 442–449. 10.1161/CIRCULATIONAHA.106.668392 - DOI - PMC - PubMed

[2] Antzelevitch C., Pollevick G. D., Cordeiro J. M., Casis O., Sanguinetti M. C., Aizawa Y., et al. . (2007). Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation 115, 442–449. 10.1161/CIRCULATIONAHA.106.668392 - DOI - PMC - PubMed

[3] Betzenhauser M. J., Pitt G. S., Antzelevitch C. (2015). Calcium channel mutations in cardiac arrhythmia syndromes. Curr. Mol. Pharmacol. 8, 133–142. 10.2174/1874467208666150518114857 - DOI - PMC - PubMed

[4] Betzenhauser M. J., Pitt G. S., Antzelevitch C. (2015). Calcium channel mutations in cardiac arrhythmia syndromes. Curr. Mol. Pharmacol. 8, 133–142. 10.2174/1874467208666150518114857 - DOI - PMC - PubMed

[5] Bourdin B., Shakeri B., Tetreault M. P., Sauve R., Lesage S., Parent L. (2015). Functional characterization of CaValpha2delta mutations associated with sudden cardiac death. J. Biol. Chem. 290, 2854–2869. 10.1074/jbc.M114.597930 - DOI - PMC - PubMed

[6] Bourdin B., Shakeri B., Tetreault M. P., Sauve R., Lesage S., Parent L. (2015). Functional characterization of CaValpha2delta mutations associated with sudden cardiac death. J. Biol. Chem. 290, 2854–2869. 10.1074/jbc.M114.597930 - DOI - PMC - PubMed

[7] Burashnikov E., Pfeiffer R., Barajas-Martinez H., Delpon E., Hu D., Desai M., et al. . (2010). Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death. Heart Rhythm. 7, 1872–1882. 10.1016/j.hrthm.2010.08.026 - DOI - PMC - PubMed

[8] Burashnikov E., Pfeiffer R., Barajas-Martinez H., Delpon E., Hu D., Desai M., et al. . (2010). Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death. Heart Rhythm. 7, 1872–1882. 10.1016/j.hrthm.2010.08.026 - DOI - PMC - PubMed

[9] Ciconte G., Monasky M. M., Santinelli V., Micaglio E., Vicedomini G., Anastasia L., et al. . (2020). Brugada syndrome genetics is associated with phenotype severity. Eur. Heart J. 42:1082–90. 10.1093/eurheartj/ehaa942 - DOI - PMC - PubMed

[10] Ciconte G., Monasky M. M., Santinelli V., Micaglio E., Vicedomini G., Anastasia L., et al. . (2020). Brugada syndrome genetics is associated with phenotype severity. Eur. Heart J. 42:1082–90. 10.1093/eurheartj/ehaa942 - DOI - PMC - PubMed

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Commentary: Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome

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Commentary: Peptide-Based Targeting of the L-Type Calcium Channel Corrects the Loss-of-Function Phenotype of Two Novel Mutations of the CACNA1 Gene Associated With Brugada Syndrome

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