Chlorella vulgaris in combination with high intensity interval training in overweight and obese women: a randomized double-blind clinical trial

J Diabetes Metab Disord. 2021 May 31;20(1):781-792. doi: 10.1007/s40200-021-00816-0. eCollection 2021 Jun.


Background: Chlorella vulgaris (CV) as a multifunctional dietary supplement is known with lots of health benefits. It is possible that CV consumption along with high-intensity interval training (HIIT), a short period exercise is more beneficial. This investigation aimed to evaluate the effects of CV and/or HIIT on anthropometric parameters and cardiometabolic risk factors among overweight or obese women.

Methods: Present randomized double-blind clinical trial, included 46 women with overweight or obesity and randomly assigned them to four groups including CV, HIIT, CV+HIIT, and placebo. CV supplementation was 900 mg a day and HIIT program 3 sessions a week. Dietary intake, anthropometric assays and blood samples were taken at the commencement and completion of 8-week intervention.

Results: After 8 weeks, waist circumference (WC) significantly reduced in CV+HIIT group in comparison with placebo group. Significant decreases in triglycerides (TG) and low-density lipoprotein (LDL) cholesterol levels were found after CV supplementation and/or HIIT exercise in comparison with placebo group. A significant rise in high-density lipoprotein (HDL) cholesterol level was observed in HIIT and HIIT + CV groups in comparison with placebo group, however CV consumption failed to affect HDL cholesterol levels. CV and/or HIIT significantly lowered, visceral adiposity index (VAI), lipid accumulating product (LAP) and atherogenic index of plasma (AIP) in comparison with placebo. However, concurrent administration of CV and HII resulted in greater reduction in this indexes. Among glycemic indices a significant reduction in insulin resistance in CV+HIIT group compared with placebo group were seen.

Conclusions: In conclusion, CV and HIIT could improve lipid profile and glycemic status in overweight and obese women.

Keywords: Chlorella vulgaris (CV); High Intensity Interval Training (HIIT); Obesity.