5-Aminosalicylic acid as enemas or suppositories in distal ulcerative colitis?

J Clin Gastroenterol. 1988 Aug;10(4):406-9. doi: 10.1097/00004836-198808000-00012.


Thirty-nine patients with documented active distal proctitis (less than 20 cm) received either 5-aminosalicylic acid (5-ASA) enemas (2 g in 100 ml) or suppositories 1 g b.i.d., in a controlled study. Twenty patients received enemas, while 19 patients received suppositories, for 30 days. No difference could be observed in terms of efficacy; however, it was the patients' opinion that treatment with suppositories was easier than that with enemas (p less than 0.01).

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Rectal
  • Aminosalicylic Acids / administration & dosage*
  • Colitis, Ulcerative / drug therapy*
  • Enema
  • Humans
  • Mesalamine
  • Self Administration
  • Suppositories


  • Aminosalicylic Acids
  • Suppositories
  • Mesalamine