Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size

Clin Infect Dis. 2021 Oct 20;73(8):1528-1531. doi: 10.1093/cid/ciab587.


Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. We measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8+ T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.

Keywords: HIV-1; T-cell activation; replication-competent virus; reservoir.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Retroviral Agents / therapeutic use
  • CD4-Positive T-Lymphocytes
  • HIV Infections* / drug therapy
  • HIV-1*
  • Humans
  • Viral Load
  • Virus Latency
  • Virus Replication


  • Anti-Retroviral Agents