Nitric Oxide: A Unique Endogenous Signaling Molecule in Vascular Biology (Nobel Lecture)

Louis J Ignarro

doi:10.1002/(SICI)1521-3773(19990712)38:13/14<1882::AID-ANIE1882>3.0.CO;2-V

Nitric Oxide: A Unique Endogenous Signaling Molecule in Vascular Biology (Nobel Lecture)

Angew Chem Int Ed Engl. 1999 Jul 12;38(13-14):1882-1892. doi: 10.1002/(SICI)1521-3773(19990712)38:13/14<1882::AID-ANIE1882>3.0.CO;2-V.

Author

Louis J Ignarro¹

Affiliation

¹ Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA 90095 (USA), Fax: (+1) 310-825-6267.

Abstract

"Endothelium-derived relaxing factor (EDRF) must be nitric oxide." Although there was much experimental evidence that effects on or actions of EDRF were identical to those of nitric oxide, proposing this hypothesis certainly meant going out on a limb. However, once this discovery was made increased investigation indicated the physiological significance of nitric oxide in vascular biology.

Keywords: Enzymes; Neurotransmitters; Nitric oxide; Nobel lecture; Signal transduction.

Publication types

Review