Protective role of taurine against oxidative stress (Review)

Mol Med Rep. 2021 Aug;24(2):605. doi: 10.3892/mmr.2021.12242. Epub 2021 Jun 29.

Abstract

Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer protection against oxidant stress. The development of hypertension, muscle/neuro‑​associated disorders, hepatic cirrhosis, cardiac dysfunction and ischemia/reperfusion are examples of some injuries that are linked with oxidative stress. The present review gives a comprehensive description of all the underlying mechanisms of taurine, with the aim to explain its anti‑oxidant actions. Taurine is regarded as a cytoprotective molecule due to its ability to sustain normal electron transport chain, maintain glutathione stores, upregulate anti‑oxidant responses, increase membrane stability, eliminate inflammation and prevent calcium accumulation. In parallel, the synergistic effect of taurine with other potential therapeutic modalities in multiple disorders are highlighted. Apart from the results derived from research findings, the current review bridges the gap between bench and bedside, providing mechanistic insights into the biological activity of taurine that supports its potential therapeutic efficacy in clinic. In the future, further clinical studies are required to support the ameliorative effect of taurine against oxidative stress.

Keywords: cardiotoxicity; hepatotoxicity; neurotoxicity; oxidative stress; taurine; therapeutics.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Antioxidants / physiology
  • Antioxidants / therapeutic use
  • Heart Diseases / drug therapy
  • Homeostasis / drug effects
  • Homeostasis / physiology
  • Humans
  • Liver Diseases / drug therapy
  • Muscular Diseases / drug therapy
  • Nervous System Diseases / drug therapy
  • Oxidative Stress / drug effects*
  • Taurine / pharmacology*
  • Taurine / physiology
  • Taurine / therapeutic use

Substances

  • Antioxidants
  • Taurine

Grants and funding

The present study was supported by The State Scholarships Foundation (I.K.Y; grant no. 2018-050-0502-13155). This work was also supported by the European Infrastructure For Translational Medicine-Greece project (grant no. MIS 5028091) which is implemented under the Action ‘Reinforcement of the Research and Innovation Infrastructure’, funded by the Operational Program ‘Competitiveness, Entrepreneurship and Innovation’ (grant no. NSRF 2014-2020) and co-financed by Greece and the European Union (European Regional Development Fund).