Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial

doi:10.1515/jcim-2020-0090

Randomized Controlled Trial

. 2020 Dec 25;18(2):405-411.

doi: 10.1515/jcim-2020-0090.

Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial

Hadi Bazyar¹, Seyed Ahmad Hosseini², Sirous Saradar³, Delsa Mombaini², Mohammad Allivand², Maryam Labibzadeh⁴, Meysam Alipour⁵

Affiliations

¹ Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
² Nutrition and Metabolic Diseases Researcher Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
³ Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁴ Institute for Higher Education ACECR, Khouzestan, Iran.
⁵ Alimentary Tract Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

PMID: 34187117
DOI: 10.1515/jcim-2020-0090

Randomized Controlled Trial

Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial

Hadi Bazyar et al. J Complement Integr Med. 2020.

. 2020 Dec 25;18(2):405-411.

doi: 10.1515/jcim-2020-0090.

Authors

Hadi Bazyar¹, Seyed Ahmad Hosseini², Sirous Saradar³, Delsa Mombaini², Mohammad Allivand², Maryam Labibzadeh⁴, Meysam Alipour⁵

Affiliations

¹ Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
² Nutrition and Metabolic Diseases Researcher Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
³ Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁴ Institute for Higher Education ACECR, Khouzestan, Iran.
⁵ Alimentary Tract Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

PMID: 34187117
DOI: 10.1515/jcim-2020-0090

Abstract

Background: In patients with type 2 diabetes mellitus (T2DM) the inflammatory and metabolic responses to epigallocatechin-3-gallate (EGCG) are unknown.

Objectives: Evaluate the impacts of EGCG on metabolic factors and some biomarkers of stress oxidative in patients with T2DM.

Methods: In this randomized, double-blind, placebo-controlled trial, 50 patients with T2DM consumed either 2 tablets (300 mg) EGCG (n=25) or wheat flour as placebo (n=25) for 2 months. The total antioxidant capacity (TAC), interleukin-6 (IL-6), lipid profile, mean arterial pressure (MAP), atherogenic index of plasma (AIP) were evaluated before and after the intervention.

Results: The finding of present study exhibited a significant increase in the serum levels of TAC after the EGCG supplementation (p=0.001). Also, in compare with control group, the mean changes of TAC were significantly higher in supplement group (p=0.01). In intervention group, a significant decrease was observed in the mean levels of triglyceride, total cholesterol, diastolic blood pressure (DBP), AIP, and MAP (p<0.05). Taking EGCG resulted in the mean changes of total cholesterol, MAP and DBP were significantly lower in compare with control group (p<0.05).

Conclusions: This study recommended that EGCG supplementation may be improved blood pressure, lipid profile, AIP, and oxidative status in patients with T2DM.

Keywords: EGCG; inflammation; lipid profile; type 2 diabetes mellitus.

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References

1. Javid, AZ, Hosseini, SA, Gholinezhad, H, Moradi, L, Haghighi-zadeh, MH, Bazyar, H. Antioxidant and anti-inflammatory properties of melatonin in patients with type 2 diabetes mellitus with periodontal disease under non-surgical periodontal therapy: a double-blind, placebo-controlled trial. Diabetes, metabolic syndrome and obesity. Targets and Therapy 2020;13:753–61.
1. Ogurtsova, K, da Rocha Fernandes, J, Huang, Y, Linnenkamp, U, Guariguata, L, Cho, N, et al.. IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract 2017;128:40–50. https://doi.org/10.1016/j.diabres.2017.03.024.
1. Bazyar, H, Adibmanesh, A, Javid, AZ, Maghsoumi-Norouzabad, L, Gravand, E, Alipour, M, et al.. The relationship between metabolic factors and anthropometric indices with periodontal status in type 2 diabetes mellitus patients with chronic periodontitis. Obes Med 2019;16:100138. https://doi.org/10.1016/j.obmed.2019.10013.
1. Tiwari, BK, Pandey, KB, Abidi, A, Rizvi, SI. Markers of oxidative stress during diabetes mellitus. J Biomark 2013;2013:378790. https://doi.org/10.1155/2013/378790.
1. Rehman, K, Akash, MSH. Mechanism of generation of oxidative stress and pathophysiology of type 2 diabetes mellitus: how are they interlinked?. J Cell Biochem 2017;118:3577–85. https://doi.org/10.1002/jcb.26097.

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[1] Javid, AZ, Hosseini, SA, Gholinezhad, H, Moradi, L, Haghighi-zadeh, MH, Bazyar, H. Antioxidant and anti-inflammatory properties of melatonin in patients with type 2 diabetes mellitus with periodontal disease under non-surgical periodontal therapy: a double-blind, placebo-controlled trial. Diabetes, metabolic syndrome and obesity. Targets and Therapy 2020;13:753–61.

[2] Javid, AZ, Hosseini, SA, Gholinezhad, H, Moradi, L, Haghighi-zadeh, MH, Bazyar, H. Antioxidant and anti-inflammatory properties of melatonin in patients with type 2 diabetes mellitus with periodontal disease under non-surgical periodontal therapy: a double-blind, placebo-controlled trial. Diabetes, metabolic syndrome and obesity. Targets and Therapy 2020;13:753–61.

[3] Ogurtsova, K, da Rocha Fernandes, J, Huang, Y, Linnenkamp, U, Guariguata, L, Cho, N, et al.. IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract 2017;128:40–50. https://doi.org/10.1016/j.diabres.2017.03.024.

[4] Ogurtsova, K, da Rocha Fernandes, J, Huang, Y, Linnenkamp, U, Guariguata, L, Cho, N, et al.. IDF Diabetes Atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract 2017;128:40–50. https://doi.org/10.1016/j.diabres.2017.03.024.

[5] Bazyar, H, Adibmanesh, A, Javid, AZ, Maghsoumi-Norouzabad, L, Gravand, E, Alipour, M, et al.. The relationship between metabolic factors and anthropometric indices with periodontal status in type 2 diabetes mellitus patients with chronic periodontitis. Obes Med 2019;16:100138. https://doi.org/10.1016/j.obmed.2019.10013.

[6] Bazyar, H, Adibmanesh, A, Javid, AZ, Maghsoumi-Norouzabad, L, Gravand, E, Alipour, M, et al.. The relationship between metabolic factors and anthropometric indices with periodontal status in type 2 diabetes mellitus patients with chronic periodontitis. Obes Med 2019;16:100138. https://doi.org/10.1016/j.obmed.2019.10013.

[7] Tiwari, BK, Pandey, KB, Abidi, A, Rizvi, SI. Markers of oxidative stress during diabetes mellitus. J Biomark 2013;2013:378790. https://doi.org/10.1155/2013/378790.

[8] Tiwari, BK, Pandey, KB, Abidi, A, Rizvi, SI. Markers of oxidative stress during diabetes mellitus. J Biomark 2013;2013:378790. https://doi.org/10.1155/2013/378790.

[9] Rehman, K, Akash, MSH. Mechanism of generation of oxidative stress and pathophysiology of type 2 diabetes mellitus: how are they interlinked?. J Cell Biochem 2017;118:3577–85. https://doi.org/10.1002/jcb.26097.

[10] Rehman, K, Akash, MSH. Mechanism of generation of oxidative stress and pathophysiology of type 2 diabetes mellitus: how are they interlinked?. J Cell Biochem 2017;118:3577–85. https://doi.org/10.1002/jcb.26097.

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Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial

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Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial

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