Inhibition of lysine methyltransferase G9a/GLP reinstates long-term synaptic plasticity and synaptic tagging/capture by facilitating protein synthesis in the hippocampal CA1 area of APP/PS1 mouse model of Alzheimer's disease

Transl Neurodegener. 2021 Jun 29;10(1):23. doi: 10.1186/s40035-021-00247-0.

Javan Lee Tze Han^{1

2}, Karen Ka Lam Pang^{1

2}, Sheila Rui Xia Ang^{1

2}, Mahima Sharma^{1

2}, Sreedharan Sajikumar^{3

4

5}

¹ Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.
² Neurobiology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.
³ Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. phssks@nus.edu.sg.
⁴ Neurobiology Programme, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore. phssks@nus.edu.sg.
⁵ Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore. phssks@nus.edu.sg.

No abstract available

Publication types