A pilot study evaluating the efficacy and tolerability of a comprehensive, hydrating topical antioxidant developed specifically for men

J Cosmet Dermatol. 2021 Sep;20(9):2816-2823. doi: 10.1111/jocd.14314. Epub 2021 Aug 3.

Abstract

Introduction: There is growing interest in skincare products designed for men. This pilot study evaluated the efficacy and tolerability of a comprehensive antioxidant product in men.

Methods: This 12-week study evaluated improvements from baseline in erythema, lines/wrinkles, skin tone, texture, brightness, dryness/flaking and pores (6-point scale), global improvements (5-point scale), and sebum levels following daily application in males with mild to moderate photodamaged skin. Subject self-assessments and adverse events (AEs) were captured.

Results: Twenty-two subjects completed the study. Early mean percent improvements from baseline were demonstrated in all categories at week 4 with visible improvements in skin tone (29%; p = .0001) and pores (28%; p < .0001). Reductions in skin surface sebum levels (forehead region) from baseline were demonstrated at 8 (p < .0001) and 12 (p < .0003) weeks. Ninety-six percent of subjects reported overall visible improvement of their skin and that the study product calmed/soothed skin, reducing redness and irritation after shaving. One subject reported mild dryness.

Conclusion: Once daily application of a comprehensive topical antioxidant designed for men led to significant improvements in skin appearance, substantial reductions in skin surface sebum levels, and was well tolerated with a high level of subject satisfaction over 12 weeks.

Keywords: antioxidants; hydration; male skin; pores; sebum reduction; skincare.

MeSH terms

  • Antioxidants* / adverse effects
  • Humans
  • Male
  • Pilot Projects
  • Skin Aging*
  • Skin Cream
  • Treatment Outcome

Substances

  • Antioxidants

Grants and funding