A radioimmunoassay of 3 tumor markers and 13 hormones was performed before therapy in 166 laryngeal cancer patients with relation to tumor spreading. The levels of these markers and hormones excluding testosterone, were within control indices recommended in instructions for certain test kits. At the same time direct correlation was found between the content of ferritin, calcitonin, parathormone and tumor spreading. Testosterone concentration in all the patients was below the control level. Control of the hormonal status of laryngeal cancer patients was recommended during therapy with the use of radiomodifying agents to determine the effect of various radiomodifiers on the endocrine system, for the assessment of therapeutic efficacy and, probably, the prediction of the course of the disease.