Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition

Cell Commun Signal. 2021 Jun 30;19(1):67. doi: 10.1186/s12964-021-00750-x.


Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progression, invasion and metastasis in human cancer. With the ever-growing evidence supporting the role of epithelial-mesenchymal transition (EMT) in invasion and metastasis, so does our understanding of the role SFKs play in mediating these processes. Here we describe some key mechanisms through which Src family kinases play critical role in epithelial homeostasis and how their function is essential for the propagation of invasive signals. Video abstract.

Keywords: Actin cytoskeleton; Epithelial-to-mesenchymal transition; Invasion; Metastasis; Src family kinases; Treatment resistance; Unique domain.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Epithelial-Mesenchymal Transition*
  • Humans
  • Models, Biological
  • Signal Transduction
  • src-Family Kinases / chemistry
  • src-Family Kinases / metabolism*


  • Adaptor Proteins, Signal Transducing
  • src-Family Kinases