Functional Peptides That Target Biomembranes: Design and Modes of Action

Chem Pharm Bull (Tokyo). 2021;69(7):601-607. doi: 10.1248/cpb.c21-00140.


Biomembranes are important targets in molecular design. Our laboratory has been exploring the design of functional peptides that modulate membrane barrier function, lipid packing, and structure. Evaluation of the results obtained and analyses of cellular mechanisms have yielded peptides with more refined designs and functions. This review highlights the progress made in our laboratory towards the development of unique peptides that modulate membrane properties.

Keywords: antibody; cell membrane; curvature; endocytosis; intracellular delivery; peptide.

Publication types

  • Review

MeSH terms

  • Arginine / chemistry
  • Cell Membrane / chemistry
  • Cell Membrane / metabolism*
  • Cell Membrane Permeability / drug effects
  • Cell-Penetrating Peptides / chemistry
  • Cell-Penetrating Peptides / metabolism
  • Cell-Penetrating Peptides / pharmacology
  • Endosomes / metabolism
  • Humans
  • Peptides / chemistry
  • Peptides / metabolism*
  • Peptides / pharmacology


  • Cell-Penetrating Peptides
  • Peptides
  • Arginine