Thermoregulatory effects of guava leaf extract-menthol toner application for post-exercise use

Pharm Biol. 2021 Dec;59(1):854-859. doi: 10.1080/13880209.2021.1942925.

Abstract

Context: Psidium guajava L. (Myrtaceae) leaf contains a wide variety of bioactive compounds that contribute valuable effects on human well-being.

Objective: This study investigates the influence of guava leaf extract-menthol toner on thermoregulation, including perspiration, skin temperature, and recovery heart rate.

Materials and methods: This randomised, placebo-controlled clinical trial assessed the effects of the guava leaf extract-menthol toner and placebo with a 1-week washout period. Sixty-four participants were enrolled. The participants exercised on a treadmill until a 75% heart rate reserve was achieved for 5 min, followed by a 5 min post-exercise rest period. The skin temperature and heart rate were then measured before 5 mL of the testing product was sprayed to specific areas of the body, left it for 30 sec before wiped off. Post-exercise perspiration and skin temperatures were collected by sweat patches and measured by the Skin-thermometer ST500, respectively. A 20 min heart rate monitoring period started 10 min after the exercise and measured every 2 min intervals.

Results: Use of the toner significantly reduced post-exercise perspiration to approximately half of the baseline and placebo use values (p < 0.05). Furthermore, relative heart rate changes showed no significant differences among the tests (p > 0.05). Skin temperature was also unaffected (p > 0.05).

Discussion and conclusion: Guava leaf extract-menthol toner reduced perspiration by astringent effects but did not influence heat dissipation and did not affect cardiovascular mechanism compared to the controls. Additional cleaning with guava leaf extract-menthol toner could offer better hygiene after a workout.

Keywords: Astringent; heat dissipation; personal hygiene; skin temperature; sweating.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Body Temperature Regulation / drug effects*
  • Cross-Over Studies
  • Exercise / physiology*
  • Exercise Test
  • Female
  • Heart Rate / drug effects
  • Humans
  • Male
  • Menthol / chemistry
  • Plant Extracts / pharmacology*
  • Plant Leaves
  • Psidium / chemistry*
  • Single-Blind Method
  • Skin Temperature / drug effects
  • Sweating / drug effects
  • Young Adult

Substances

  • Plant Extracts
  • Menthol