Curcumin and Its Potential Impact on Microbiota

Nutrients. 2021 Jun 10;13(6):2004. doi: 10.3390/nu13062004.


Curcumin is one of the most frequently researched herbal substances; however, it has been reported to have a poor bioavailability and fast metabolism, which has led to doubts about its effectiveness. Curcumin has antioxidant and anti-inflammatory effects, and has demonstrated favorable health effects. Nevertheless, well-reported in vivo pharmacological activities of curcumin are limited by its poor solubility, bioavailability, and pharmacokinetic profile. The bidirectional interactions between curcumin and gut microbiota play key roles in understanding the ambiguity between the bioavailability and biological activity of curcumin, including its wider health impact.

Keywords: antioxidant; curcumin; health; microbiota.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Availability
  • Curcumin / metabolism
  • Curcumin / pharmacology*
  • Disease
  • Exercise / physiology
  • Health
  • Humans
  • Microbiota / drug effects*


  • Curcumin