The LPA 3 Receptor: Regulation and Activation of Signaling Pathways

Int J Mol Sci. 2021 Jun 23;22(13):6704. doi: 10.3390/ijms22136704.


The lysophosphatidic acid 3 receptor (LPA3) participates in different physiological actions and in the pathogenesis of many diseases through the activation of different signal pathways. Knowledge of the regulation of the function of the LPA3 receptor is a crucial element for defining its roles in health and disease. This review describes what is known about the signaling pathways activated in terms of its various actions. Next, we review knowledge on the structure of the LPA3 receptor, the domains found, and the roles that the latter might play in ligand recognition, signaling, and cellular localization. Currently, there is some information on the action of LPA3 in different cells and whole organisms, but very little is known about the regulation of its function. Areas in which there is a gap in our knowledge are indicated in order to further stimulate experimental work on this receptor and on other members of the LPA receptor family. We are convinced that knowledge on how this receptor is activated, the signaling pathways employed and how the receptor internalization and desensitization are controlled will help design new therapeutic interventions for treating diseases in which the LPA3 receptor is implicated.

Keywords: GRK; LPA3; PKC; lysophosphatidic acid; lysophosphatidic acid 3 receptor; receptor phosphorylation.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / metabolism
  • Embryo Implantation
  • Fertility
  • Humans
  • Myocardium / metabolism
  • Neoplasms / metabolism
  • Phosphorylation
  • Receptors, Lysophosphatidic Acid / chemistry*
  • Receptors, Lysophosphatidic Acid / metabolism*
  • Signal Transduction


  • Antioxidants
  • Receptors, Lysophosphatidic Acid