Antibody Response Following a Two-Dose mRNA Vaccination Regimen, in Health Care Workers of a Tertiary Hospital in Athens, Greece

Elissavet Kontou; Kyriaki Ranellou; Dimitrios Zoulas; Anastasia Bletsa; Eirini Rompola; Evangelia-Theophano Piperaki; Nikolaos Athanasiou; Kleio Ampelakiotou; Maria Pratikaki; Christina Stergiopoulou; Athina Argyropoulou; Androula Alevra; Aggeliki Megalou; Alexandra Tsirogianni

doi:10.3390/jpm11060576

Antibody Response Following a Two-Dose mRNA Vaccination Regimen, in Health Care Workers of a Tertiary Hospital in Athens, Greece

J Pers Med. 2021 Jun 19;11(6):576. doi: 10.3390/jpm11060576.

Authors

Affiliations

¹ Immunology-Histocompatibility Department, "Evangelismos" General Hospital, 10676 Athens, Greece.
² Microbiology Department, "Evangelismos" General Hospital, 10676 Athens, Greece.
³ Blood Bank Department, "Evangelismos" General Hospital, 10676 Athens, Greece.
⁴ Clinical Biochemistry Department, "Evangelismos" General Hospital, 10676 Athens, Greece.
⁵ Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
⁶ St ICU, "Evangelismos" General Hospital, 10676 Athens, Greece.

Abstract

We analyzed the antibody responses of 564 hospital workers in Athens, Greece, after vaccination with two doses of the BNT162b2 (Comirnaty^®; BioNTech and Pfizer) mRNA COVID-19 vaccine. A greater antibody increase was observed in women, younger age groups, previously infected individuals and personnel working in COVID-19 clinics. Notably, individuals with a prior COVID-19 infection mounted a significantly higher antibody titer following the first dose than the rest of the population; the same was true for those working in COVID-19 clinics, even without history of previous infection.

Keywords: SARS CoV-2; antibody response; healthcare workers; mRNA vaccine.