TCL1A, B Cell Regulation and Tolerance in Renal Transplantation

Cells. 2021 Jun 1;10(6):1367. doi: 10.3390/cells10061367.


Despite much progress in the management of kidney transplantation, the need for life-long immunosuppressive therapies remains a major issue representing many risks for patients. Operational tolerance, defined as allograft acceptance without immunosuppression, has logically been subject to many investigations with the aim of a better understanding of post-transplantation mechanisms and potentially how it would be induced in patients. Among proposed biomarkers, T-cell Leukemia/Lymphoma protein 1A (TCL1A) has been observed as overexpressed in the peripheral blood of operational tolerant patients in several studies. TCL1A expression is restricted to early B cells, also increased in the blood of tolerant patients, and showing regulatory properties, notably through IL-10 secretion for some subsets. TCL1A has first been identified as an oncogene, overexpression of which is associated to the development of T and B cell cancer. TCL1A acts as a coactivator of the serine threonine kinase Akt and through other interactions favoring cell survival, growth, and proliferation. It has also been identified as interacting with others major actors involved in B cells differentiation and regulation, including IL-10 production. Herein, we reviewed known interactions and functions of TCL1A in B cells which could involve its potential role in the set up and maintenance of renal allograft tolerance.

Keywords: Akt; Breg; IL-10; TCL1A; kidney transplantation; tolerance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • B-Lymphocytes / immunology*
  • Cell Differentiation / immunology*
  • Humans
  • Interleukin-10 / immunology
  • Kidney Transplantation*
  • Proto-Oncogene Proteins / immunology*
  • Proto-Oncogene Proteins c-akt / immunology
  • T-Lymphocytes / immunology
  • Transplantation Tolerance*


  • IL10 protein, human
  • Proto-Oncogene Proteins
  • TCL1A protein, human
  • Interleukin-10
  • Proto-Oncogene Proteins c-akt