Gastritis, Gastric Polyps and Gastric Cancer

Int J Mol Sci. 2021 Jun 18;22(12):6548. doi: 10.3390/ijms22126548.


Gastric cancer is still an important disease causing many deaths worldwide, although there has been a marked reduction in prevalence during the last few decades. The decline in gastric cancer prevalence is due to a reduction in Helicobacter pylori infection which has occurred for at least 50 years. The most probable mechanism for the carcinogenic effect of H. pylori is hypergastrinemia since H. pylori infected individuals do not have increased risk of gastric cancer before the development of oxyntic atrophy. When atrophy has developed, the carcinogenic process continues independent of H. pylori. Autoimmune gastritis also induces oxyntic atrophy leading to marked hypergastrinemia and development of ECL cell neoplasia as well as adenocarcinoma. Similarly, long-term treatment with efficient inhibitors of acid secretion like the proton pump inhibitors (PPIs) predisposes to ECL cell neoplasia of a different degree of malignancy. Contrasting the colon where most cancers develop from polyps, most polyps in the stomach have a low malignant potential. Nevertheless, gastric polyps may also give rise to cancer and have some risk factors and mechanisms in common with gastric cancer. In this overview the most common gastric polyps, i.e., hyperplastic polyps, adenomatous polyps and fundic gland polyps will be discussed with respect to etiology and particularly use of PPIs and relation to gastric carcinogenesis.

Keywords: ECL cell; gastric cancer; gastric polyps; gastrin; gastritis.

Publication types

  • Review

MeSH terms

  • Adenomatous Polyps / etiology*
  • Adenomatous Polyps / pathology
  • Adenomatous Polyps / therapy
  • Animals
  • Gastritis / complications
  • Gastritis / immunology
  • Gastritis / microbiology*
  • Gastritis / pathology
  • Helicobacter pylori / pathogenicity
  • Humans
  • Stomach Neoplasms / etiology*
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / therapy

Supplementary concepts

  • Polyposis, Gastric