Prostate Cancer Predisposition

Urol Clin North Am. 2021 Aug;48(3):283-296. doi: 10.1016/j.ucl.2021.03.001. Epub 2021 Jun 12.


The identification and characterization of alterations in prostate cancer (PCa)-predisposing genes can help to inform screening strategies in undiagnosed men and treatment options in men in both the clinically localized and in the metastatic setting. This review provides an overview of the genetic basis underlying hereditary predisposition to PCa, the current role of genetics and PCa risk assessment, and how genetic risk factors affect aggressiveness and lethality of PCa.

Keywords: Cancer susceptibility gene; Hereditary cancer syndrome; Polygenic risk score; Prostate cancer.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Biomarkers, Tumor / genetics
  • Disease Progression
  • Genetic Predisposition to Disease*
  • Genetic Testing
  • Germ-Line Mutation
  • Humans
  • Male
  • Polymorphism, Single Nucleotide
  • Prostatic Neoplasms / epidemiology
  • Prostatic Neoplasms / ethnology
  • Prostatic Neoplasms / genetics*
  • Risk Factors


  • Biomarkers, Tumor