Infant T-cell acute lymphoblastic leukaemia with t(6;7) (TCRB-MYB) translocation

Br J Haematol. 2021 Aug;194(3):613-616. doi: 10.1111/bjh.17609. Epub 2021 Jul 1.

Abstract

T-ALL is rare in infancy with only 10 (1.5%) of 651 patients of that subtype in the Interfant-06 infant ALL trial. We report 3 cases of t(6;7) (TCR/MYB) infant T-cell Acute Lymphoblastic Leukaemia who appear to have a distinct clinical presentation with CNS disease and refractory disease or late relapse.

Keywords: T-Acute Lymphoblastic Leukaemia; infant.

Publication types

  • Case Reports

MeSH terms

  • Genes, T-Cell Receptor beta
  • Humans
  • Infant
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Proto-Oncogene Proteins c-myb / genetics*
  • Receptors, Antigen, T-Cell, alpha-beta / genetics*
  • Translocation, Genetic

Substances

  • MYB protein, human
  • Proto-Oncogene Proteins c-myb
  • Receptors, Antigen, T-Cell, alpha-beta