U shape association of hemoglobin level with in-hospital mortality for COVID-19 patients

Toshiki Kuno; Matsuo So; Mai Takahashi; Natalia N Egorova

doi:10.1007/s11239-021-02516-1

U shape association of hemoglobin level with in-hospital mortality for COVID-19 patients

J Thromb Thrombolysis. 2022 Jan;53(1):113-117. doi: 10.1007/s11239-021-02516-1. Epub 2021 Jul 2.

Authors

Toshiki Kuno¹, Matsuo So², Mai Takahashi², Natalia N Egorova³

Affiliations

¹ Department of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, First Avenue, 16th street, New York, NY, 10003, USA. Toshiki.Kuno@mountsinai.org.
² Department of Medicine, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, First Avenue, 16th street, New York, NY, 10003, USA.
³ Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Abstract

Our hypothesis was that high hemoglobin (Hb) level might be associated with hypercoagulable state and death due to COVID-19. Of the 9467 hospitalized COVID-19 patients, patients were subdivided into 5 groups based on the level of Hb; Hb < 10 g/dL, 10 g/dL ≤ Hb < 12 g/dL, 12 g/dL ≤ Hb < 14 g/dL, 14 g/dL ≤ Hb < 16 g/dL, and Hb ≥ 16 g/dL. Compared to patients with 12 g/dL ≤ Hb < 14 g/dL, patients with Hb ≥ 16 g/dL had significantly higher adjusted in-hospital mortality (OR [95% CI] 1.62 [1.15-2.27], P = 0.005).

Keywords: COVID-19; Hemoglobin; Mortality.

MeSH terms

COVID-19* / mortality
Hemoglobins* / analysis
Hospital Mortality*
Humans

Substances

Hemoglobins