Lost in post-translational modification-Dengue virus writes its own sequel

Sci Immunol. 2021 Jul 2;6(61):eabk1555. doi: 10.1126/sciimmunol.abk1555.

Authors

Soumya S Yandamuri¹, Kevin C O'Connor¹

Affiliation

¹ Departments of Neurology and Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. soumya.yandamuri@yale.edu kevin.oconnor@yale.edu.

PMID: 34215681
DOI: 10.1126/sciimmunol.abk1555

Abstract

Elevated frequency of afucosylated IgG1 antibodies during dengue virus infection is associated with prior infection and predicts severe disease.

Copyright © 2021, American Association for the Advancement of Science.

MeSH terms

Antibodies, Viral / blood*
Antibodies, Viral / metabolism*
Dengue Virus / immunology*
Glycosylation
Humans
Immunoglobulin G / blood
Immunoglobulin G / metabolism
Protein Processing, Post-Translational / physiology*
Severe Dengue / immunology*
Severe Dengue / pathology

Substances

Antibodies, Viral
Immunoglobulin G