Retrospective Analysis of the Serovars and Antibiogram of Vibrio cholerae Isolates of the 2017 Ilorin Cholera Outbreak, Nigeria

Dele Ohinoyi Amadu; Idris Nasir Abdullahi; Ezekiel Seibu; Abayomi Fadeyi; Khadeejah Kamaldeen; Aliu Ajibola Akanbi; Chukwudi Crescent Okwume; Motunrayo Bukola Amadu; Charles Nwabuisi

doi:10.3947/ic.2021.0001

Retrospective Analysis of the Serovars and Antibiogram of Vibrio cholerae Isolates of the 2017 Ilorin Cholera Outbreak, Nigeria

Infect Chemother. 2021 Jun;53(2):368-373. doi: 10.3947/ic.2021.0001.

Authors

Dele Ohinoyi Amadu¹, Idris Nasir Abdullahi², Ezekiel Seibu¹, Abayomi Fadeyi¹, Khadeejah Kamaldeen³, Aliu Ajibola Akanbi¹, Chukwudi Crescent Okwume⁴, Motunrayo Bukola Amadu⁵, Charles Nwabuisi⁵

Affiliations

¹ Department of Medical Microbiology and Parasitology, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
² Department of Medical Laboratory Science, Faculty of Allied Health Sciences, Ahmadu Bello University, Zaria, Nigeria. eedris888@yahoo.com.
³ Kwara State Ministry of Health, Ilorin, Nigeria.
⁴ Department of Medical Laboratory Services, University of Nigeria Teaching Hospital, Enugu, Nigeria.
⁵ Department of Obstetrics and Gynecology, University of Ilorin Teaching Hospital, Ilorin, Nigeria.

Abstract

In this retrospective study, we determined the incidence, serovars, and antibiogram of Vibrio cholerae isolated from 102 clinical stool samples collected from rice water diarrheic patients during an outbreak (May - July 2017) in Ilorin metropolis, Nigeria. The culture positive rate of the V. cholerae isolates was 41.2%, with 41 and 1 isolates from O1 (Inaba) and non-O1/O139 serogroups, respectively. The isolates were the most susceptible to ciprofloxacin (76.2%) followed by amoxicillin-clavulanate (71.4%). However, all isolates were resistant to ampicillin and tetracycline. In conclusion, V. cholerae O1 was the predominant circulating serogroup exhibiting multi-drug resistance during the outbreak.

Keywords: Antibiogram; Cholera; Nigeria; Serovars; Waterborne.