Estimation of an EORTC QLU-C10 Value Set for Spain Using a Discrete Choice Experiment

Pharmacoeconomics. 2021 Sep;39(9):1085-1098. doi: 10.1007/s40273-021-01058-x. Epub 2021 Jul 3.


Background: The EORTC QLU-C10D is a preference-based measure derived from the EORTC QLQ-C30. For use in economic evaluations, country-specific value sets are needed. This study aimed to generate an EORTC QLU-C10 value set for Spain.

Methods: A sample of the Spanish general population completed an online discrete choice experiment. An attribute-balanced incomplete block design was used to select 960 choice tasks, with a total of 1920 health states. Each participant was randomly assigned 16 choice sets without replacement. Data were modelled using generalized estimating equations and mixed logistic regressions.

Results: A total of 1625 panel members were invited to participate, 1010 of whom were included in the study. Dimension decrements were generally monotonic with larger disutilities at increased severity levels. Dimensions associated with larger decrements were physical functioning and pain, while the dimension with the smallest decrement was sleep disturbances. The PITS state (i.e. worst attainable health) for the Spanish population is - 0.043.

Conclusions: This study generated the first Spanish value set for the QLU-C10D. This can facilitate cost-utility analyses when applied to data collected with the EORTC QLQ-C30.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Cost-Benefit Analysis
  • Humans
  • Logistic Models
  • Quality of Life*
  • Spain
  • Surveys and Questionnaires