"Vitamin D supplementation and COVID-19 treatment: A systematic review and meta-analysis"

Diabetes Metab Syndr. Jul-Aug 2021;15(4):102189. doi: 10.1016/j.dsx.2021.102189. Epub 2021 Jun 28.

Abstract

Background: Vitamin-D is an immune-modulator which might be linked to disease severity by SARS-CoV-2.

Methods: Meta-analysis of RCTs and quasi-experimental studies, evaluating the role of vitamin-D supplementation in COVID patients was done.

Results: Total 5 studies (3 RCTs and 2 Quasi-experimental) including n = 467 patients were included. Vitamin D didn't reduce mortality (RR 0.55, 95%CI 0.22 to 1.39, p = 0.21), ICU admission rates (RR 0.20, 95% CI 0.01-4.26, p = 0.3) and need for invasive ventilation (RR 0.24, 95% CI 0.01-7.89, p = 0.42).

Conclusion: No significant difference with vitamin-D supplementation on major health related outcomes in COVID-19. Well-designed RCTs are required addressing this topic.

Keywords: COVID pneumonia; COVID-19; SARS-CoV-2; Vitamin-D.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • COVID-19 / drug therapy*
  • COVID-19 / epidemiology
  • COVID-19 / virology
  • Dietary Supplements*
  • Humans
  • Nutrition Therapy / methods*
  • Prognosis
  • SARS-CoV-2 / drug effects*
  • Vitamin D / administration & dosage*
  • Vitamins / administration & dosage*

Substances

  • Vitamins
  • Vitamin D