Modeling seizures: From single neurons to networks

Seizure. 2021 Aug;90:4-8. doi: 10.1016/j.seizure.2021.06.015. Epub 2021 Jun 17.


Dynamical system tools offer a complementary approach to detailed biophysical seizure modeling, with a high potential for clinical applications. This review describes the theoretical framework that provides a basis for theorizing certain properties of seizures and for their classification according to their dynamical properties at onset and offset. We describe various modeling approaches spanning different scales, from single neurons to large-scale networks. This narrative review provides an accessible overview of this field, including non-exhaustive examples of key recent works.

Publication types

  • Review

MeSH terms

  • Humans
  • Models, Neurological*
  • Neurons
  • Seizures*