Follicle-stimulating hormone receptor autoantibody associated primary ovarian insufficiency successfully treated with corticosteroids: a case report

Carrie Riestenberg; Susan Ahern; Mousa Shamonki

doi:10.1016/j.xfre.2020.09.002

Follicle-stimulating hormone receptor autoantibody associated primary ovarian insufficiency successfully treated with corticosteroids: a case report

F S Rep. 2020 Sep 14;1(3):206-208. doi: 10.1016/j.xfre.2020.09.002. eCollection 2020 Dec.

Authors

Carrie Riestenberg¹, Susan Ahern², Mousa Shamonki³

Affiliations

¹ Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California-Los Angeles, Los Angeles, California.
² Division of Endocrinology, Department of Medicine, University of California-Los Angeles, Ventura, California.
³ Fertility & Surgical Associates of California, Thousand Oaks, California.

Abstract

Objective: To report a case of successful controlled ovarian stimulation (COH) for oocyte cryopreservation in a patient with autoimmune primary ovarian insufficiency (POI) and polyglandular autoimmune syndrome (PGAS) type 2.

Design: Case report.

Setting: Private in vitro fertilization clinic.

Patients: 25-Year-old woman, G0, with autoimmune POI and PGAS type 2.

Interventions: Diagnosis of autoimmune interference with FSH signaling, with subsequent high-dose corticosteroid immune suppression and successful oocyte cryopreservation.

Main outcomes measures: Successful stimulation with exogenous gonadotropins, oocyte retrieval, and cryopreservation.

Results: Retrieval and cryopreservation of 36 metaphase-II (MII) oocytes.

Conclusions: Scrutiny of POI cases will facilitate identification of a subset of patients in whom immune suppression with short-term, high-dose corticosteroids may enable successful COH.

Keywords: FSH receptor IgG; Primary ovarian insufficiency; autoimmunity; corticosteroids; resistant ovary syndrome.