The genes coding for human pro alpha 1(IV) collagen and pro alpha 2(IV) collagen are both located at the end of the long arm of chromosome 13

Am J Hum Genet. 1988 Feb;42(2):309-14.


We have isolated and characterized a cDNA clone containing DNA sequences coding for the noncollagenous carboxy-terminal domain of human pro alpha 2(IV) collagen. Using this cDNA clone in both Southern blot analysis of DNA isolated from human-mouse somatic-cell hybrids and in situ hybridization of normal human metaphase chromosomes, we have demonstrated that the gene coding for human pro alpha 2(IV) collagen is located at 13q33----34, in the same position on chromosome 13 as the pro alpha 1(IV) collagen gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Banding
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 13*
  • Collagen / genetics*
  • DNA / genetics
  • Genetic Linkage
  • Genetic Markers
  • Humans
  • Hybrid Cells
  • Karyotyping
  • Mice
  • Nucleic Acid Hybridization
  • Procollagen / genetics*


  • Genetic Markers
  • Procollagen
  • Collagen
  • DNA