Innate Immune Regulation of Dermatitis

Immunol Allergy Clin North Am. 2021 Aug;41(3):347-359. doi: 10.1016/j.iac.2021.04.011. Epub 2021 Jun 5.


Dermatitis encompasses a spectrum of inflammatory skin disorders with aberrant immune responses classified as type 1, type 2, and/or type 3. Major advances in the understanding of the pathogenesis of atopic dermatitis (AD) have shed new light on how innate immune responses critically regulate type 2 inflammation and itch. This article highlights the diverse ways by which type 2 immune cells regulate diseases beyond AD. The discovery of human Mas-related G protein-coupled receptor X2 on mast cells has revealed novel T cell-independent and immunoglobulin E-independent mechanisms of allergic contact dermatitis-associated and urticarial itch, respectively.

Keywords: Allergic contact dermatitis (ACD); Atopic dermatitis (AD); Itch; Janus kinase (JAK); Mas-related G protein–coupled receptor (MRGPR); Mast cells; Urticaria.

Publication types

  • Review

MeSH terms

  • Dermatitis, Allergic Contact*
  • Dermatitis, Atopic*
  • Humans
  • Immunity, Innate
  • Mast Cells
  • Pruritus