APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All

doi:10.1001/jamaneurol.2021.1649

Comment

. 2021 Aug 1;78(8):913-915.

doi: 10.1001/jamaneurol.2021.1649.

APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All

Cynthia A Lemere¹, Elizabeth Head², David M Holtzman³

Affiliations

¹ Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
² Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine.
³ Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, Missouri.

PMID: 34228117
DOI: 10.1001/jamaneurol.2021.1649

Comment

APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All

Cynthia A Lemere et al. JAMA Neurol. 2021.

. 2021 Aug 1;78(8):913-915.

doi: 10.1001/jamaneurol.2021.1649.

Authors

Cynthia A Lemere¹, Elizabeth Head², David M Holtzman³

Affiliations

¹ Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
² Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine.
³ Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, Missouri.

PMID: 34228117
DOI: 10.1001/jamaneurol.2021.1649

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Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome.
Bejanin A, Iulita MF, Vilaplana E, Carmona-Iragui M, Benejam B, Videla L, Barroeta I, Fernandez S, Altuna M, Pegueroles J, Montal V, Valldeneu S, Giménez S, González-Ortiz S, Muñoz L, Padilla C, Aranha MR, Estellés T, Illán-Gala I, Belbin O, Camacho V, Wilson LR, Annus T, Osorio RS, Videla S, Lehmann S, Holland AJ, Zetterberg H, Blennow K, Alcolea D, Clarimon J, Zaman SH, Blesa R, Lleó A, Fortea J. Bejanin A, et al. JAMA Neurol. 2021 Aug 1;78(8):937-947. doi: 10.1001/jamaneurol.2021.1893. JAMA Neurol. 2021. PMID: 34228042 Free PMC article.

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APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All

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APOE ε4 Association With Cognition and Alzheimer Disease Biomarkers in Down Syndrome-Implications for Clinical Trials and Treatments for All

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