Recent advances in regenerative medicine strategies for cancer treatment

Biomed Pharmacother. 2021 Sep:141:111875. doi: 10.1016/j.biopha.2021.111875. Epub 2021 Jul 3.

Abstract

Cancer stands as one of the most leading causes of death worldwide, while one of the most significant challenges in treating it is revealing novel alternatives to predict, diagnose, and eradicate tumor cell growth. Although various methods, such as surgery, chemotherapy, and radiation therapy, are used today to treat cancer, its mortality rate is still high due to the numerous shortcomings of each approach. Regenerative medicine field, including tissue engineering, cell therapy, gene therapy, participate in cancer treatment and development of cancer models to improve the understanding of cancer biology. The final intention is to convey fundamental and laboratory research to effective clinical treatments, from the bench to the bedside. Proper interpretation of research attempts helps to lessen the burden of treatment and illness for patients. The purpose of this review is to investigate the role of regenerative medicine in accelerating and improving cancer treatment. This study examines the capabilities of regenerative medicine in providing novel cancer treatments and the effectiveness of these treatments to clarify this path as much as possible and promote advanced future research in this field.

Keywords: Cancer treatment; Cell therapy; Gene therapy; Regenerative medicine; Tissue engineering.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell- and Tissue-Based Therapy / methods
  • Cell- and Tissue-Based Therapy / trends*
  • Genetic Therapy / methods
  • Genetic Therapy / trends*
  • Humans
  • Immunotherapy, Adoptive / methods*
  • Immunotherapy, Adoptive / trends
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / therapy*
  • Regenerative Medicine / methods
  • Regenerative Medicine / trends*
  • Tissue Engineering / methods
  • Tissue Engineering / trends
  • Treatment Outcome