Single-cell profiling reveals the dynamics of cytomegalovirus-specific T cells in haploidentical hematopoietic stem cell transplantation

Jasper J P Van Beek; Simone Puccio; Alessandra Roberto; Federica De Paoli; Giulia Graziano; Elisa Salviato; Giorgia Alvisi; Veronica Zanon; Alice Scarpa; Elisa Zaghi; Michela Calvi; Clara Di Vito; Rossana Mineri; Barbara Sarina; Chiara De Philippis; Armando Santoro; Jacopo Mariotti; Stefania Bramanti; Francesco Ferrari; Luca Castagna; Domenico Mavilio; Enrico Lugli

doi:10.3324/haematol.2020.276352

Single-cell profiling reveals the dynamics of cytomegalovirus-specific T cells in haploidentical hematopoietic stem cell transplantation

Haematologica. 2021 Oct 1;106(10):2768-2773. doi: 10.3324/haematol.2020.276352.

Authors

Jasper J P Van Beek¹, Simone Puccio¹, Alessandra Roberto¹, Federica De Paoli¹, Giulia Graziano², Elisa Salviato², Giorgia Alvisi¹, Veronica Zanon¹, Alice Scarpa¹, Elisa Zaghi¹, Michela Calvi¹, Clara Di Vito³, Rossana Mineri¹, Barbara Sarina¹, Chiara De Philippis¹, Armando Santoro⁴, Jacopo Mariotti¹, Stefania Bramanti¹, Francesco Ferrari⁵, Luca Castagna¹, Domenico Mavilio⁶, Enrico Lugli¹

Affiliations

¹ IRCCS Humanitas Research Hospital, Rozzano, Milan.
² IFOM, the FIRC Institute of Molecular Oncology, Milan.
³ Department of Medical Biotechnologies and Translational Medicine (BioMeTra), University of Milan, Milan.
⁴ IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan.
⁵ IFOM, the FIRC Institute of Molecular Oncology, Milan, Italy; IGM-CNR, Institute of Molecular Genetics "Luigi Luca Cavalli Sforza", National Research Council, Pavia.
⁶ IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy; Department of Medical Biotechnologies and Translational Medicine (BioMeTra), University of Milan, Milan.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cytomegalovirus
Cytomegalovirus Infections*
Graft vs Host Disease*
Hematopoietic Stem Cell Transplantation*
Humans
T-Lymphocytes
Transplantation Conditioning

Grants and funding

Funding: this work was funded by the European Research Council (ERC-StG-2014 PERSYST #640511 to EL). SP was supported by a fellowship from the Fondazione Italiana per la Ricerca sul Cancro- Associazione Italiana per la Ricerca sul Cancro (FIRC-AIRC). The purchase of a FACSymphony A5 was defrayed in part by a grant from the Italian Ministry of Health (agreement 82/2015).