Abstract
Cannabidiol and other cannabinoids are being used more frequently for sports medicine-related conditions. This review will help sports medicine clinicians answer questions that their athletes and active patients have about the potential effectiveness of cannabinoids on common sports medicine conditions. In the article, the authors compare cannabidiol and delta-9-tetrahydrocannabinol effects, noting the difference on the endocannabinoid and nonendocannabinoid receptors. The theoretical benefits of these two compounds and the current legality in the United States surrounding cannabidiol and delta-9-tetrahydrocannabinol use also are addressed.
Copyright © 2021 by the American College of Sports Medicine.
MeSH terms
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Athletic Performance
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Brain Concussion / drug therapy
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Cannabidiol / adverse effects
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Cannabidiol / metabolism
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Cannabidiol / therapeutic use*
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Cannabinoids / adverse effects
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Cannabinoids / metabolism
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Cannabinoids / therapeutic use*
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Cannabis / chemistry
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Cannabis / classification
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Chronic Pain / drug therapy
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Dronabinol / metabolism
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Dronabinol / therapeutic use
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Endocannabinoids / metabolism
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Endocannabinoids / pharmacology
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Humans
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Medical Marijuana
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Osteoarthritis / drug therapy
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Receptor, Serotonin, 5-HT1A / metabolism
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Receptors, Cannabinoid / metabolism
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Sports Medicine*
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TRPV Cation Channels / metabolism
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United States
Substances
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Cannabinoids
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Endocannabinoids
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GPR55 protein, human
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Medical Marijuana
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Receptors, Cannabinoid
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TRPV Cation Channels
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TRPV1 protein, human
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Receptor, Serotonin, 5-HT1A
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Cannabidiol
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Dronabinol