A facile chemoenzymatic synthesis of SARS-CoV-2 glycopeptides for probing glycosylation functions

Chem Commun (Camb). 2021 Jul 8;57(55):6804-6807. doi: 10.1039/d1cc02790e.


Glycosylation plays important roles in SARS-CoV-2 infection. We describe here a facile chemoenzymatic synthesis of core-fucosylated N-glycopeptides derived from the SARS-CoV-2 Spike protein and their binding with glycan-dependent neutralizing antibody S309 and human lectin CLEC4G. The synthetic glycopeptides provide tools for further functional characterization of viral glycosylation.

MeSH terms

  • Antibodies, Neutralizing / immunology
  • Chemistry Techniques, Synthetic
  • Glycopeptides / chemical synthesis*
  • Glycopeptides / chemistry
  • Glycopeptides / immunology
  • Glycopeptides / metabolism*
  • Glycosylation
  • Polysaccharides / metabolism
  • Spike Glycoprotein, Coronavirus / chemistry*


  • Antibodies, Neutralizing
  • Glycopeptides
  • Polysaccharides
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2