Individual EEG profiling of attention deficits in left spatial neglect: A pilot study

Neurosci Lett. 2021 Sep 14;761:136097. doi: 10.1016/j.neulet.2021.136097. Epub 2021 Jul 6.


Electrophysiological group studies in brain-damaged patients can be run to capture the EEG correlates of specific cognitive impairments. Nonetheless, this procedure is not adequate to characterize the inter-individual variability present in major neuropsychological syndromes. We tested the possibility of getting a reliable individual EEG characterization of deficits of endogenous orienting of spatial attention in right-brain damaged (RBD) patients with left spatial neglect (N+). We used a single-trial topographical analysis (STTA; [39] of individual scalp EEG topographies recorded during leftward and rightward orienting of attention with central cues in RBD patients with and without (N-) neglect and in healthy controls (HC). We found that the STTA successfully decoded EEG signals related to leftward and rightward orienting in five out of the six N+, five out of the six N- patients and in all the six HC. In agreement with findings from conventional average-group studies, successful classifications of EEG signals in N+ were observed during the 400-800 ms period post-cue-onset, which reflects preserved voluntary engagement of attention resources (ADAN component). These results suggest the possibility of acquiring reliable individual EEG profiles of neglect patients.

Keywords: ADAN; Attention; EEG; Multivariate analysis; Neglect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Attention*
  • Brain / physiopathology
  • Electroencephalography
  • Female
  • Functional Laterality
  • Humans
  • Male
  • Middle Aged
  • Perceptual Disorders / etiology
  • Perceptual Disorders / physiopathology*
  • Spatial Behavior*
  • Stroke / complications*