Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G_s

Affiliations

• ¹ iHuman Institute, ShanghaiTech University, Shanghai, China.
• ² School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
• ³ Center for Excellence in Molecular Cell Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
• ⁴ University of Chinese Academy of Sciences, Beijing, China.
• ⁵ Section of Receptor Biology & Signaling, Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.
• ⁶ Institute for Research in Immunology and Cancer, Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada.
• ⁷ Orion Pharma R&D, Espoo, Finland.
• ⁸ Departments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA, USA.
• ⁹ Section of Receptor Biology & Signaling, Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden. gunnar.schulte@ki.se.
• ¹⁰ iHuman Institute, ShanghaiTech University, Shanghai, China. xufei@shanghaitech.edu.cn.
• ¹¹ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. xufei@shanghaitech.edu.cn.
• ¹² Center for Excellence in Molecular Cell Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. xufei@shanghaitech.edu.cn.
• ¹³ University of Chinese Academy of Sciences, Beijing, China. xufei@shanghaitech.edu.cn.