Electronic cigarettes: Modern instruments for toxic lung delivery and posing risk for the development of chronic disease

Int J Biochem Cell Biol. 2021 Aug:137:106039. doi: 10.1016/j.biocel.2021.106039. Epub 2021 Jul 6.


Following the emergence of electronic cigarette, or vaping product use associated lung injury (EVALI) in 2019 in the US, regulation of e-cigarettes has become globally tighter and the collective evidence of the detrimental effects of vaping has grown. The danger of cellular distress and altered homeostasis is heavily associated with the modifiable nature of electronic cigarette devices. An array of harmful chemicals and elevated concentrations of metals have been detected in e-cigarette aerosols which have been linked to various pathogeneses. Vaping is linked to increased inflammation, altered lipid homeostasis and mitochondrial dysfunction whilst also increasing microbial susceptibility whilst the long-term damage is yet to be observed. The scientific evidence is mounting and highlighting that, along with traditional tobacco cigarette smoking, electronic cigarette vaping is not a safe practice.

Keywords: Cytotoxic; Electronic cigarettes; Respiratory disease; Vaping.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chronic Disease
  • Electronic Nicotine Delivery Systems / statistics & numerical data*
  • Humans
  • Lung Injury / etiology
  • Lung Injury / pathology*
  • Vaping / adverse effects*