Hepatocarcinogenesis: Radiology-Pathology Correlation

Magn Reson Imaging Clin N Am. 2021 Aug;29(3):359-374. doi: 10.1016/j.mric.2021.05.007.


In the background of chronic liver disease, hepatocellular carcinoma develops via a complex, multistep process called hepatocarcinogenesis. This article reviews the causes contributing to the process. Emphasis is made on the imaging manifestations of the pathologic changes seen at many stages of hepatocarcinogenesis, from regenerative nodules to dysplastic nodules and then to hepatocellular carcinoma.

Keywords: Dysplastic nodule; Hepatocarcinogenesis; Hepatocellular carcinoma; Liver; Liver reporting & data system (LI-RADS).

Publication types

  • Review

MeSH terms

  • Carcinoma, Hepatocellular* / diagnostic imaging
  • Humans
  • Liver Neoplasms* / diagnostic imaging
  • Magnetic Resonance Imaging
  • Radiography
  • Radiology*