Hippo-YAP signaling in digestive system tumors

Feng Yin; Jixin Dong; Liang-I Kang; Xiuli Liu

Hippo-YAP signaling in digestive system tumors

Am J Cancer Res. 2021 Jun 15;11(6):2495-2507. eCollection 2021.

Authors

Feng Yin¹, Jixin Dong², Liang-I Kang³, Xiuli Liu⁴

Affiliations

¹ Department of Pathology and Anatomical Sciences, University of Missouri Columbia, Missouri, USA.
² Eppley Institute for Research in Cancer and Allied Diseases, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center Omaha, Nebraska, USA.
³ Department of Pathology and Immunology, Washington University School of Medicine St. Louis, Missouri, USA.
⁴ Department of Pathology, Immunology and Lab Medicine, University of Florida Gainesville, Florida, USA.

PMID: 34249412
PMCID: PMC8263672

Abstract

The Hippo pathway is an evolutionally conserved pathway and plays an important role in regulating tissue hemostasis and organ size control. Deregulation of the Hippo pathway is implicated in various human digestive system tumors. The past two decades have witnessed the discovery and elucidation of key signaling components and molecular mechanisms of the Hippo pathway. Among these, the signaling transducers YAP/TAZ are in the center of this complex network to sense and respond to extracellular cues such as cell contact, matrix stiffness and growth factors. In this review, we summarize the biological and clinical significance of Hippo-YAP signaling in the digestive system tumors, and explore the novel therapeutic strategies for targeting Hippo-YAP signaling.

Keywords: Hippo pathway; YAP; colon; esophagus; liver; pancreas; stomach; tumorigenesis.

Publication types

Review