Primary malignant giant cell tumor of the sternum

Autops Case Rep. 2021 May 25:11:e2021281. doi: 10.4322/acr.2021.281. eCollection 2021.


Primary malignant giant cell tumor (PMGCT) is a diagnosis based on the presence of a high-grade sarcomatous component along with a typical benign giant cell tumor (GCT). We report the first case of PMGCT of the sternum in a 28-year-old male with painless swelling over the manubrium sterni. The differential diagnoses of PMGCT and giant cell-rich osteosarcoma were considered. Surgical resection was performed, and the reconstruction was done with a neosternum using polymethyl methacrylate and prolene mesh. At 30 months follow-up, the patient is disease-free.

Keywords: Giant cell tumors; Neoplasms; Sternum.

Publication types

  • Review