Primary malignant giant cell tumor of the sternum

Mohammed Imaduddin; Pavithra Ayyanar; Mahesh Sultania; Dillip Muduly; Mukund Namdev Sable; Suprava Naik; Sambit Mohanty; Madhabananda Kar

doi:10.4322/acr.2021.281

Primary malignant giant cell tumor of the sternum

Autops Case Rep. 2021 May 25:11:e2021281. doi: 10.4322/acr.2021.281. eCollection 2021.

Authors

Mohammed Imaduddin¹, Pavithra Ayyanar², Mahesh Sultania¹, Dillip Muduly¹, Mukund Namdev Sable², Suprava Naik³, Sambit Mohanty⁴, Madhabananda Kar¹

Affiliations

¹ All India Institute of Medical Sciences, Department of Surgical Oncology, Sijua, Patrapada, Bhubaneswar, Odisha, India.
² All India Institute of Medical Sciences, Department of Pathology and Lab Medicine, Sijua, Patrapada, Bhubaneswar, Odisha, India.
³ All India Institute of Medical Sciences, Department of Radiodiagnosis, Sijua, Patrapada, Bhubaneswar, Odisha, India.
⁴ Prolife Diagnostics, Department of Pathology, Sijua, Patrapada, Bhubaneswar, Odisha, India.

Abstract

Primary malignant giant cell tumor (PMGCT) is a diagnosis based on the presence of a high-grade sarcomatous component along with a typical benign giant cell tumor (GCT). We report the first case of PMGCT of the sternum in a 28-year-old male with painless swelling over the manubrium sterni. The differential diagnoses of PMGCT and giant cell-rich osteosarcoma were considered. Surgical resection was performed, and the reconstruction was done with a neosternum using polymethyl methacrylate and prolene mesh. At 30 months follow-up, the patient is disease-free.

Keywords: Giant cell tumors; Neoplasms; Sternum.

Publication types

Review