Management of Pseudomonas aeruginosa lung infection in Danish cystic fibrosis patients

Acta Paediatr Scand. 1987 Nov;76(6):955-61. doi: 10.1111/j.1651-2227.1987.tb17271.x.


The annual mortality rate of cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection at the Danish CF-centre ranged from 10 to 20% in the years 1970-1975. In this period the patients received antipseudomonal chemotherapy only during acute exacerbations of infection. From 1976 99 patients acquired chronic P. aeruginosa infection and were given regular and intensive antipseudomonal treatment 3-4 times per year. The patients were followed for 612 patient-years; 7 died and the 10-year survival rate after onset of P. aeruginosa infection was 90% +/- 4%. The annual mortality rate is now 1-2%. Although precipitating antibodies against P. aeruginosa increased significantly, pulmonary function did not deteriorate with duration of infection. Cross-infection between patients caused an increased incidence of chronic P. aeruginosa infection which was reduced by hygienic measures.

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / therapeutic use*
  • Cystic Fibrosis / drug therapy
  • Cystic Fibrosis / microbiology*
  • Cystic Fibrosis / mortality
  • Denmark
  • Female
  • Follow-Up Studies
  • Humans
  • Lactams
  • Lung Diseases / drug therapy*
  • Lung Diseases / epidemiology
  • Lung Diseases / etiology
  • Male
  • Pseudomonas Infections / drug therapy*
  • Pseudomonas Infections / epidemiology
  • Pseudomonas Infections / etiology
  • Respiratory Function Tests
  • Tobramycin / therapeutic use*


  • Anti-Bacterial Agents
  • Lactams
  • Tobramycin