Exploring CNS Effects of American Traditional Medicines using Zebrafish Models

Murilo S de Abreu; Fabiano Costa; Ana C V V Giacomini; Konstantin A Demin; Elena V Petersen; Denis B Rosemberg; Allan V Kalueff

doi:10.2174/1570159X19666210712153329

Exploring CNS Effects of American Traditional Medicines using Zebrafish Models

Curr Neuropharmacol. 2022 Mar 4;20(3):550-559. doi: 10.2174/1570159X19666210712153329.

Authors

Murilo S de Abreu^{1

2

3}, Fabiano Costa⁴, Ana C V V Giacomini^{1

5}, Konstantin A Demin^{6

7

8

9}, Elena V Petersen¹, Denis B Rosemberg^{3

4

10}, Allan V Kalueff^{6

11

7

12

13

9}

Affiliations

¹ Laboratory of Cell and Molecular Biology and Neurobiology, Moscow Institute of Physics and Technology, Moscow, Russia.
² Bioscience Institute, University of Passo Fundo, Passo Fundo, RS, Brazil.
³ The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA.
⁴ Graduate Program in Biological Sciences: Toxicological Biochemistry, Natural and Exact Sciences Center, Federal University of Santa Maria, Brazil.
⁵ Graduate Program in Environmental Sciences, University of Passo Fundo, Passo Fundo, RS, Brazil.
⁶ School of Pharmacy, Southwest University, Chongqing, China.
⁷ Neurobiology Program, Sirius University of Science and Technology, Sochi, Russia.
⁸ Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia.
⁹ Institute of Translational Biomedicine SPBU, St. Petersburg State University, St. Petersburg, Russia.
¹⁰ Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Center, Federal University of Santa Maria, Brazil.
¹¹ Ural Federal University, Ekaterinburg, Russia.
¹² Granov Russian Scientific Research Center for Radiology and Surgical Technologies, St. Petersburg, Russia.
¹³ Novosibirsk State University, Novosibirsk, Russia.

Abstract

Although American traditional medicine (ATM) has been practiced for millennia, its complex multi-target mechanisms of therapeutic action remain poorly understood. Animal models are widely used to elucidate the therapeutic effects of various ATMs, including their modulation of brain and behavior. Complementing rodent models, the zebrafish (Danio rerio) is a promising novel organism in translational neuroscience and neuropharmacology research. Here, we emphasize the growing value of zebrafish for testing neurotropic effects of ATMs and outline future directions of research in this field. We also demonstrate the developing utility of zebrafish as complementary models for probing CNS mechanisms of ATM action and their potential to treat brain disorders.

Keywords: American traditional medicine; Zebrafish; animal models; behavior; brain effects; drug screening.

MeSH terms

Animals
Disease Models, Animal
Medicine, Traditional
Neuropharmacology
Neurosciences*
Zebrafish*

Abstract

MeSH terms

Grants and funding