Putting the DOT on IL1A

J Cell Biol. 2021 Aug 2;220(8):e202106164. doi: 10.1083/jcb.202106164. Epub 2021 Jul 13.


IL-1α is an upstream component of the senescence-associated secretory phenotype. In this issue, Leon et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202008101) show that DOT1L-mediated H3K79 methylation at the IL1A gene plays a key role in its induction during oncogene-induced senescence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cellular Senescence*
  • Methylation