The role of exhaustion in CAR T cell therapy

Cancer Cell. 2021 Jul 12;39(7):885-888. doi: 10.1016/j.ccell.2021.06.012.

Abstract

CAR T cell therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of CAR T cell exhaustion, its role in limiting the efficacy of CAR T therapy in both liquid and solid malignancies, and potential strategies to overcome it are discussed.

MeSH terms

  • Drug Resistance, Neoplasm*
  • Humans
  • Immunotherapy, Adoptive / methods
  • Immunotherapy, Adoptive / standards*
  • Lymphocytes, Tumor-Infiltrating / immunology*
  • Neoplasms / immunology
  • Neoplasms / therapy*
  • Receptors, Chimeric Antigen / immunology*
  • Tumor Microenvironment

Substances

  • Receptors, Chimeric Antigen