Non-coding RNAs in endodontic disease

Johnah Galicia; Asma A Khan

doi:10.1016/j.semcdb.2021.07.006

Non-coding RNAs in endodontic disease

Semin Cell Dev Biol. 2022 Apr:124:82-84. doi: 10.1016/j.semcdb.2021.07.006. Epub 2021 Jul 10.

Authors

Johnah Galicia¹, Asma A Khan²

Affiliations

¹ Department of Restorative Dentistry (Endodontics), Eastman Dental Institute, University College London, United Kingdom; Department of Endodontics, Arthur A. Dugoni School of Dentistry, San Francisco, CA, United States.
² Department of Endodontics, Dental School, UT Health San Antonio, San Antonio, TX, United States. Electronic address: KhanA2@uthscsa.edu.

PMID: 34257038
DOI: 10.1016/j.semcdb.2021.07.006

Abstract

The immunocompetence and regeneration potential of the dental pulp and its surrounding apical tissues have been investigated extensively in the field of endodontics. While research on the role of non-coding RNAs in these tissues is still in its infancy, it is envisioned that improved understanding of the regulatory function of ncRNAs in pulpal and periapical immune response will help prevent or treat endodontic disease. Of particular importance is the role of these RNAs in regenerating the dentin-pulp complex. In this review, we highlight recent progress on the role of non-coding RNAs in the immune response to endodontic infection as well as the repair and regenerative response to injury.

Keywords: Dental; Epigenetic; MicroRNA; Non-coding RNA; SiRNAs.

Publication types

Review